Search results for "pathology [Fabry Disease]"
showing 10 items of 1709 documents
Squamoid eccrine ductal carcinoma
1998
Problematic internet use prior to and during the COVID-19 pandemic
2021
The health and socio-economic challenges arising from the COVID-19 pandemic have led to greater reliance on the internet to meet basic needs and responsibilities. Greater engagement in online activities may have negative mental and physical health consequences for some vulnerable individuals, particularly under mandatory self-isolation or ‘lockdown’ conditions. The present study investigated whether changes in levels of involvement in online activities during the COVID-19 pandemic (i.e., watching TV series,online sexual activities, video games, social networks, gambling, online shopping, and instant messaging) were associated with problematic internet use, as well as whether certain psychol…
Validation of a set of reference genes to study response to herbicide stress in grasses
2012
Abstract Background Non-target-site based resistance to herbicides is a major threat to the chemical control of agronomically noxious weeds. This adaptive trait is endowed by differences in the expression of a number of genes in plants that are resistant or sensitive to herbicides. Quantification of the expression of such genes requires normalising qPCR data using reference genes with stable expression in the system studied as internal standards. The aim of this study was to validate reference genes in Alopecurus myosuroides, a grass (Poaceae) weed of economic and agronomic importance with no genomic resources. Results The stability of 11 candidate reference genes was assessed in plants res…
Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge
2017
Statins, the 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase inhibitors, are widely prescribed for treatment of hypercholesterolemia. Although statins are generally well tolerated, up to ten percent of statin-treated patients experience myalgia symptoms, defined as muscle pain without elevated creatinine phosphokinase (CPK) levels. Myalgia is the most frequent reason for discontinuation of statin therapy. The mechanisms underlying statin myalgia are not clearly understood. To elucidate changes in gene expression associated with statin myalgia, we compared profiles of gene expression in skeletal muscle biopsies from patients with statin myalgia who were undergoing statin re-challenge (cases)…
Analysis of LSD in human body fluids and hair samples applying ImmunElute columns.
2000
Immunoaffinity extraction units (LSD ImmunElute) are commercially available for the analysis of lysergic acid diethylamide (LSD) in urine. The ImmunElute resin contains immobilized monoclonal antibodies to LSD. We applied the ImmunElute procedure to serum and also to human hair samples. For hair analysis the samples were first extracted with methanol under sonication. The extracts were then purified using the ImmunElute resin. LSD analysis was carried out with HPLC and fluorescence detection. The immunoaffinity extraction provides highly purified extracts for chromatographic analysis. The limit of detection (signal-to-noise ratio = 3) has been determined to be < 50 pg regardless of which sa…
Postmortem distribution of dihydrocodeine and metabolites in a fatal case of dihydrocodeine intoxication.
1998
A report of a fatal dihydrocodeine ingestion under substitution therapy is given. Quantitation of dihydrocodeine, dihydromorphine, N-nordihydrocodeine, dihydrocodeine-6-, dihydromorphine-6- and dihydromorphine-3-glucuronide was performed simultaneously after solid-phase extraction prior to HPLC analysis, and the analytes were detected using their native fluorescence. Postmortem concentrations of blood samples from different sampling sites as well as from liver, kidney and cerebrum are reported. A hair sample was investigated to prove long-term use of the substitute drug. Site-to-site differences of the analytes from blood samples were very small. The partition behavior of the opioid glucuro…
The relationship between animal cruelty in children and adolescent and interpersonal violence: A systematic review
2019
Abstract The following study is a systematic review of the relationship between animal cruelty and interpersonal violence. The systematic literature review following PRISMA guidelines and combined with the application of inclusion and exclusion criteria, enabled us to locate 32 studies published between 1995 and July 2017. Overall, the results show that episodes of animal cruelty during childhood and adolescence tend to co-occur alongside other forms of violent and antisocial behaviors. Cruelty to animals was associated with bullying, behavioral problems, experiences of abuse (emotional, physical and sexual), and juvenile delinquency. Furthermore, recurrent animal cruelty during childhood a…
Histologic and Cytogenetic Patterns in Benign, Atypical, and Malignant Meningiomas
1995
Atypical meningiomas comprise an intermediate category of meningeal neoplasmas with some microscopic features of aggressivity and a capacity for recurrence. We present a clin ical, morphologic, and cytogenetic study of 15 meningiomas. Morphologic and cytogenetic analysis suggested the existence of morphologically typical meningiomas with normal karyotype or monosomy 22 and morphologically atypical meningiomas, with increasing chromosomal abnormalities (complex karyotype) between these two types. Present results suggest the existence of a third type of morphologically typical meningioma that lacks a phenotypical aggressivity but has a complex karyotype. These genotypical characteristics may…
A combined treatment regimen for desquamative gingivitis in patients with oral lichen planus
2007
Background: Chronic desquamative gingivitis (DG) is a condition characterized by erythema, ulceration, and desquamation of the free and attached gingiva, usually expression of a district-systemic disease, such as oral lichen planus (OLP). Methods: A combined protocol of oral hygiene and topic corticosteroid therapy was applied in 30 patients with DG associated with OLP. Plaque index (PI) and bleeding on probing (BoP) were evaluated at baseline and after 3 months. Results: PI scoring was significantly lower after treatment in anterior, posterior, and all sites (P < 0.0001) as well as in vestibular and lingual ones (P < 0.0001 and P = 0.0001, respectively). BoP measures were found to be re…
Die Feinstruktur der Sinneshaare auf den Cerci von Gryllus bimaculatus Deg. (Saltatoria, Gryllidae)
1972
1. Zu Beginn der Hautungsvorgange werden bei den dicken und dunnen Borstenhaaren die Ciliarstrukturen sowie die sie umhullenden cuticularen Scheiden verlangert. 2. Vor der Ecdysis ragen die neu angelegten Haare in den Exuvialraum. Die cuticularen Scheiden und die Ciliarstrukturen durchqueren den Exuvialraum. Sie treten bei dicken und dunnen Borstenhaaren durch die Spitze der neu angelegten Haare und ziehen im Haarlumen bis zur Haarbasis. Auf diese Weise bleiben die Ciliarstrukturen der alten Haare bis zur Ecdysis mit den zugehorigen Sinneszellen verbunden. 3. Bei der Ecdysis reisen die cuticularen Scheiden an den Spitzen der neuen Borstenhaare ab. Dadurch entsteht hier ein Porus, uber den d…